No touch problem after screen and touch IC replacement

Screen won't respond to touch. I tried updating IOS which didn't work (normally and through iTunes where I would get error 6)

The home button works fine, and the iPad has never been dropped or had any water damage. A replaced digitizer didn't work but replacing the touch IC worked temporarily. However, when the touchscreen stopped being responsive again after 2 weeks and replacing the touch IC a second time didn't work.

Would reballing the CPU fix both the touch and updating problem? What else could be the issue?